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That is, did the studyanswer the research questions and provide credible evidence? For the quantitative designsthat we discuss first, internal validity addresses whether variance was controlled appro-priately to provide an uncontaminated picture of the relationship between the independentand dependent variables. It serves as a mode of intracel-lular communication, carrying molecules and informationalong the microtubules and intermediate filaments from theaxon terminal to the nerve cell body and from the nerve cellbody to the axon terminal.

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Inactivation of Mdm2 in mice leads to perma-nent p53 activation, causing embryonic lethality and the lethal phenotype was com-pletely rescued by p53 inactivation supporting the critical role of Mdm2 in p53regulation [44]. Phototoxicity A sunburn-like or othersevere skin reaction on exposed parts is seenin some individuals.

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